The research of integrin-targeted anticancer agents has recorded important advancements
in ingenious design of delivery systems, based either on the prodrug approach, or on …

EMT and pathogenesis: the good, the bad and the ugly• TGF‐b—a central player in EMT•
Changes in cell–cell/cell–ECM adhesion in EMT—the role of integrins during EMT• TGF‐b …

To penetrate solid tumors, low molecular weight (Mw< 10 KDa) compounds have an edge
over antibodies: their higher penetration because of their small size. Because of the dense …

A cell surface receptor for thyroid hormone has recently been identified on the extracellular
domain of integrin αvβ3. In a variety of human and animal cell lines this hormone receptor …

The public health has declared an international state of emergency due to the spread of a
new coronavirus (SARS-CoV-2) representing a real pandemic threat so that to find potential …

The mesenchymal sub-type of triple negative breast cancer (MES-TNBC) has a highly
aggressive behavior and worse prognosis, due to its invasive and stem-like features, that …

Background Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-
matrix adhesion processes. Among them, α V β 3 integrin, that recognizes the aminoacidic …

Purpose: To test whether a novel bifunctional chimeric peptide comprising a cyclic Arg-Gly-
Asp pentapeptide covalently bound to an echistatin domain can discriminate αvβ3 from αvβ5 …

The critical role of integrins in tumor progression and metastasis has stimulated intense
efforts to identify pharmacological agents that can modulate integrin function. In recent …

Herein, we report the synthesis and biological characterization of the new peptide
ψRGDechi as the first step toward novel-targeted theranostics in melanoma. This …