Discoveries in cancer research are rarely so exceptional that they both cause immediate
changes in the treatment of patients and dramatically advance our understanding of the …

All-trans retinoic acid (ATRA) is an active metabolite of vitamin A under the family retinoid.
Retinoids, through their cognate nuclear receptors, exert potent effects on cell growth …

Background All-trans-retinoic acid induces complete remission in acute promyelocytic
leukemia. However, it is not clear whether induction therapy with all-trans-retinoic acid is …

We designed a multicenter randomized trial comparing chemotherapy with daunorubicin-
Ara C (chemotherapy group) and all transretinoic acid (ATRA) combined to the same …

All-trans retinoic acid (RA) has proven a major advance in the treatment of acute
promyelocytic leukemia (APL). However, the proper management of patients who present …

Arsenic trioxide (As2O3) is an effective therapy for acute promyelocytic leukemia (APL), and
there has been promising activity noted in other hematologic and solid tumors. The …

To turn a disease from highly fatal to highly curable is extremely difficult, especially when the
disease is a type of cancer. However, we can gain some insight into how this can be done …

Chromosomal translocation t (11; 17)(q23; 21) is associated with a retinoic acid-resistant
form of acute promyelocytic leukemia. The translocation fuses the RARα gene to thePLZF …

All-trans retinoic acid (ATRA) can induce complete remission (CR) in most patients with
acute promyelocytic leukemia (APL) through in vivo differentiation of APL blasts. However, it …

In each case of acute promyelocytic leukemia (APL) one of three PML-RARα mRNA types is
produced, depending on the break/fusion site in the PML gene that is linked to a common …