[PDF][PDF] 15 years of GWAS discovery: Realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
[PDF][PDF] Using genetic association data to guide drug discovery and development: Review of methods and applications
Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …
expensive and slow to obtain. In contrast, evidence from conventional observational …
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt
Abstract The Open Targets Platform (https://platform. opentargets. org/) is an open source
resource to systematically assist drug target identification and prioritisation using publicly …
resource to systematically assist drug target identification and prioritisation using publicly …
[PDF][PDF] Virus exposure and neurodegenerative disease risk across national biobanks
With recent findings connecting the Epstein-Barr virus to an increased risk of multiple
sclerosis and growing concerns regarding the neurological impact of the coronavirus …
sclerosis and growing concerns regarding the neurological impact of the coronavirus …
[HTML][HTML] Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study
P Li, H Wang, L Guo, X Gou, G Chen… - BMC …, 2022 - bmcmedicine.biomedcentral.com
Several recent observational studies have reported that gut microbiota composition is
associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia …
associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia …
[PDF][PDF] Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
[HTML][HTML] A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
DE Coral, J Fernandez-Tajes, N Tsereteli… - Nature …, 2023 - nature.com
Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in
the consequences of both conditions and the mechanisms of action are poorly defined. Here …
the consequences of both conditions and the mechanisms of action are poorly defined. Here …
[HTML][HTML] Genetic risk factors have a substantial impact on healthy life years
The impact of genetic variation on overall disease burden has not been comprehensively
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …
[HTML][HTML] Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study
Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
[PDF][PDF] Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk
Transcriptomics data have been integrated with genome-wide association studies (GWASs)
to help understand disease/trait molecular mechanisms. The utility of metabolomics …
to help understand disease/trait molecular mechanisms. The utility of metabolomics …