Epigenetics is a rapidly developing science that has gained a lot of interest in recent years
due to the correlation between characteristic epigenetic marks and cardiovascular diseases …

BACKGROUND: Heart failure, characterized by cardiac remodeling, is associated with
abnormal epigenetic processes and aberrant gene expression. Here, we aimed to elucidate …

The number of “omics” approaches is continuously growing. Among others, epigenetics has
appeared as an attractive area of investigation by the cardiovascular research community …

Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more
common in women than men, and we hypothesize that mitochondrial sex differences might …

The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic
metabolism. Many genes induced in response to pharmacologic LXR agonism have been …

Aims Post-natal maturation of mammalian cardiomyocytes proceeds rapidly after birth, with
most of the myocytes exiting cell cycle, becoming binucleated, and adopting oxidative …

BACKGROUND: Cardiac hypertrophy is an intermediate stage in the development of heart
failure. The structural and functional processes occurring in cardiac hypertrophy include …

Understanding of molecular mechanisms contributing to the pathophysiology of
endometriosis, and upstream drivers of lesion formation, remains limited. Using a C57Bl/6 …

Heart failure is a clinical syndrome with rising global incidence and poor prognosis despite
improvements in medical therapy. There is increasing research interest in epigenetic …

Background: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be used
as a source for cell delivery to remuscularize the heart after myocardial infarction. Despite …