In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

Molecular chaperones have recently emerged as fundamental regulators of salient
biological routines, including metabolic adaptations to environmental changes. Yet, many of …

Anthracycline antibiotic doxorubicin (DOX) belongs among the most important
antineoplastics used in cancer therapy. Unfortunately, its cytostatic effect in therapeutic …

Doxorubicin (DOX) therapy is limited by both cancer cells resistance and cardiotoxicity. DOX
biotransformation to doxorubicinol (DOXol) by reductases enzymes (mainly by CBR1; …

Pharmacological modulation of transcription factors (TFs) has only met little success over the
past four decades. This is mostly due to standard drug discovery approaches centered on …

Biology-oriented synthesis (BIOS) represents an alternative approach for the generation of
compound collections for biological applications. In BIOS, biologically relevant and …

Abstract Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/
reductase superfamily, reduces a variety of carbonyl compounds including therapeutic …

Abstract Carbonyl reductase 1 (CBR1), an enzyme belonging to the short-chain
dehydrogenases/reductases family, has been detected in all human tissues. CBR1 …

Anacardic acid derivatives exhibit a broad range of biological activities. In this report, an
efficient method for the synthesis of anacardic acid derivatives was explored, and a small set …

Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/
reductase superfamily, reduces anthracycline anticancer drugs to their less potent …