Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

Objective Concern exists about possible problems with later-in-life brain health, such as
cognitive impairment, mental health problems and neurological diseases, in former athletes …

Background Football (soccer) players might be at increased risk of neurodegenerative
disease, which has led to questions regarding the safety of the sport and recent measures …

Background Neurodegenerative disorders have been reported in elite athletes who
participated in contact sports. The incidence of neurodegenerative disease among former …

Whereas the diagnosis of moderate and severe traumatic brain injury (TBI) is readily visible
on current medical imaging paradigms (magnetic resonance imaging [MRI] and computed …

Traumatic brain injury (TBI) causes cognitive impairment but it remains contested regarding
which cognitive domains are most affected. Further, moderate-severe TBI is known to be …

Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head
trauma, including concussion and asymptomatic subconcussive impacts. CTE was first …