Multicomponent reactions (MCRs) are generally defined as reactions where more than two
staring materials react to form a product, incorporating essentially all of the atoms of the …

With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …

Benzodiazepines (BZDs), a diverse class of benzofused seven-membered N-heterocycles,
display essential pharmacological properties and play vital roles in some biochemical …

The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has
resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in …

An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of
stereochemically and skeletally diverse small molecules. In the build phase, a series of …

1.1. Background Reaction and separation are the two important aspects of organic
synthesis. Traditional solutionphase synthesis emphasizes reaction, while resinbased solid …

A four-component coupling process involving sequential reactions of aldehydes, primary
amines, acid chlorides, and nucleophiles has been developed to prepare multifunctional …

A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-
catalyzed intramolecular amidation of aryl iodide has been developed for rapid access to …

The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent
multicomponent reaction (MCRs) that has sparked organic chemists' interest in the field. It …

This review details a now established area within the isonitrile multi-component reaction
(IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the …