Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Pathophysiology of acute respiratory distress syndrome and COVID-19 lung injury

KE Swenson, ER Swenson - Critical care clinics, 2021 - criticalcare.theclinics.com
Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …

Ventilator-induced lung injury

JR Beitler, A Malhotra… - Clinics in chest …, 2016 - chestmed.theclinics.com
As with most medical and pharmacologic interventions, mechanical ventilation must be
titrated within a therapeutic window, providing the required lifesustaining support while …

Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome

N Nin, A Muriel, O Peñuelas, L Brochard… - Intensive care …, 2017 - Springer
Purpose To analyze the relationship between hypercapnia developing within the first 48 h
after the start of mechanical ventilation and outcome in patients with acute respiratory …

Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

S Herold, NM Gabrielli, I Vadász - American Journal of …, 2013 - journals.physiology.org
In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

Fifty Years of Research in ARDS.Gas Exchange in Acute Respiratory Distress Syndrome

P Radermacher, SM Maggiore… - American journal of …, 2017 - atsjournals.org
Acute respiratory distress syndrome (ARDS) is characterized by severe impairment of gas
exchange. Hypoxemia is mainly due to intrapulmonary shunt, whereas increased alveolar …

Hypercapnia in COPD: causes, consequences, and therapy

B Csoma, MR Vulpi, S Dragonieri, A Bentley… - Journal of Clinical …, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder that
may lead to gas exchange abnormalities, including hypercapnia. Chronic hypercapnia is an …

Resolution of pulmonary edema. Thirty years of progress

MA Matthay - American journal of respiratory and critical care …, 2014 - atsjournals.org
In the last 30 years, we have learned much about the molecular, cellular, and physiological
mechanisms that regulate the resolution of pulmonary edema in both the normal and the …

Elevated CO2 levels cause mitochondrial dysfunction and impair cell proliferation

CU Vohwinkel, E Lecuona, H Sun, N Sommer… - Journal of Biological …, 2011 - ASBMB
Elevated CO 2 concentrations (hypercapnia) occur in patients with severe lung diseases.
Here, we provide evidence that high CO 2 levels decrease O 2 consumption and ATP …

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АИ Ярошецкий, АИ Грицан, СН Авдеев… - Анестезиология и …, 2020 - cyberleninka.ru
Рекомендации Общероссийской общественной организации «Федерация
анестезиологов и реаниматологов» посвящены современному состоянию проблемы …