Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

N Hashida, K Nishida - Advanced Drug Delivery Reviews, 2023 - Elsevier
Effective drug therapy for vitreoretinal disease is a major challenge in the field of
ophthalmology; various protective systems, including anatomical and physiological barriers …

Pathogenesis and current therapies for non-infectious uveitis

X Wu, M Tao, L Zhu, T Zhang, M Zhang - Clinical and Experimental …, 2023 - Springer
Non-infectious uveitis (NIU) is a disorder with various etiologies and is characterized by eye
inflammation, mainly affecting people of working age. An accurate diagnosis of NIU is crucial …

Subconjunctival injection of rapamycin-loaded polymeric microparticles for effective suppression of noninfectious uveitis in rats

L Mo, M Deng, J Chen, S Huai, L Du, X Xu… - International Journal of …, 2024 - Elsevier
Noninfective uveitis is a major cause of vision impairment, and corticosteroid medication is a
mainstay clinical strategy that causes severe side effects. Rapamycin (RAPA), a potent …

AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?

B Castro, JC Steel, CJ Layton - Expert Reviews in Molecular …, 2024 - cambridge.org
Glaucoma and uveitis are non-vascular ocular diseases which are among the leading
causes of blindness and visual loss. These conditions have distinct characteristics and …

Sirolimus-loaded intravitreal implant for effective treatment of experimental uveitis

MRBD Paiva, DV Vasconcelos-Santos, LC Vieira… - AAPS …, 2021 - Springer
Non-infectious uveitis, an ocular inflammatory condition that affects the iris, ciliary body,
choroid, and adjacent tissues (retina, optic nerve, and vitreous), is an important cause of …

[HTML][HTML] Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 Axis

Q Jiang, Z Li, Y Huang, Z Huang, J Chen… - … & Visual Science, 2024 - tvst.arvojournals.org
Purpose: The aim of this study was to elucidate the effect of itaconate (ITA) on experimental
autoimmune uveitis (EAU), to explore its potential mechanism, and to identify potential …

Long-term outcomes of noninfectious uveitis treated with systemic immunomodulatory therapy: a retrospective case series

T Felfeli, M Balas, F Tai, A Eshtiaghi, J Rhee… - Canadian Journal of …, 2024 - Elsevier
Objective To study the clinical characteristics and long-term outcomes of patients with
noninfectious uveitis (NIU) who are treated with systemic immunomodulatory therapy (IMT) …

The efficacy and safety of infliximab in refractory noninfectious uveitis: a meta-analysis of observational studies

A Xiong, D Liu, H Chen, G Yang, C Xiong… - Frontiers in …, 2021 - frontiersin.org
Background: Although infliximab has been recommended for the second-line treatment of
seronegative spondyloarthropathy-or juvenile idiopathic arthritis-related uveitis, the issue of …

Comparative efficacy and safety of advanced intravitreal therapeutic agents for noninfectious uveitis: a systematic review and network meta-analysis

W Liao, Z Zhong, G Su, X Feng, P Yang - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: To compare the efficacy and safety of advanced intravitreal therapeutic
regimens, including a dexamethasone implant at 350 and 700 μg; a fluocinolone acetonide …

[HTML][HTML] Progress in the Use of Glucocorticoids and Biological Agents in Non-Infectious Uveitis

Y Liu, X Zou, S Cheng, Z Zhang - Journal of Biosciences and Medicines, 2024 - scirp.org
One of the main immune-mediated diseases that lead to avoidable blindness is non-
infectious uveitis. Glucocorticoids are the first-line therapy choice for noninfectious uveitis; …