Harnessing synthetic biology to engineer organoids and tissues
The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …
Global Literature Analysis of Organoid and Organ‐on‐Chip Research
J Shoji, RP Davis, CL Mummery… - Advanced healthcare …, 2023 - Wiley Online Library
Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …
physiological, or pathological states of tissues and organs. These technologies are widely …
[HTML][HTML] Pluripotent stem cell-derived model of the post-implantation human embryo
BAT Weatherbee, CW Gantner, LK Iwamoto-Stohl… - Nature, 2023 - nature.com
The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …
Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids
In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
Cynomolgus monkey embryo model captures gastrulation and early pregnancy
J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang… - Cell Stem Cell, 2023 - cell.com
Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
[HTML][HTML] Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development
KYC Lau, H Rubinstein, CW Gantner, R Hadas… - Cell Stem Cell, 2022 - cell.com
Several in vitro models have been developed to recapitulate mouse embryogenesis solely
from embryonic stem cells (ESCs). Despite mimicking many aspects of early development …
from embryonic stem cells (ESCs). Despite mimicking many aspects of early development …
[HTML][HTML] Ex utero monkey embryogenesis from blastocyst to early organogenesis
Y Gong, B Bai, N Sun, B Ci, H Shao, T Zhang, H Yao… - Cell, 2023 - cell.com
The third and fourth weeks of gestation in primates are marked by several developmental
milestones, including gastrulation and the formation of organ primordia. However, our …
milestones, including gastrulation and the formation of organ primordia. However, our …
The evolution of embryo models
M Zernicka-Goetz - Nature Methods, 2023 - nature.com
The evolution of embryo models | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …
[HTML][HTML] Multimodal characterization of murine gastruloid development
Gastruloids are 3D structures generated from pluripotent stem cells recapitulating
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …
Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous extracellular matrix
C Martins‐Costa, VA Pham, J Sidhaye… - The EMBO …, 2023 - embopress.org
The establishment and maintenance of apical‐basal polarity is a fundamental step in brain
development, instructing the organization of neural progenitor cells (NPCs) and the …
development, instructing the organization of neural progenitor cells (NPCs) and the …