Pathophysiological roles of chronic low‐grade inflammation mediators in polycystic ovary syndrome

M Rostamtabar, S Esmaeilzadeh… - Journal of cellular …, 2021 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in
reproductive‐aged women. Its basic characteristics are ovulatory dysfunction and ovarian …

Virus–host interactions in foot-and-mouth disease virus infection

K Li, C Wang, F Yang, W Cao, Z Zhu… - Frontiers in …, 2021 - frontiersin.org
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals,
which has been regarded as a persistent challenge for the livestock industry in many …

Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials …

P Guisado-Vasco, S Valderas-Ortega… - …, 2020 - thelancet.com
Background The COVID-19 outbreak challenges the Spanish health system since March
2020. Some available therapies (antimalarials, antivirals, biological agents) were grounded …

Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats

ASM Khalil, N Giribabu, S Yelumalai, H Shahzad… - Life sciences, 2021 - Elsevier
Diabetes mellitus (DM) may lead to testicular-related infertility while Myristic acid (MA) is
beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes …

[HTML][HTML] Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

W Yang, X Bai, X Luan, J Min, X Tian, H Li, H Li, W Sun… - Cell reports, 2022 - cell.com
The inflammatory response is tightly regulated, but its regulatory principles are still
incompletely understood. Cyclophilin A (CypA) has long been considered as a pro …

Cyclophilin A/CD147 interaction: A promising target for anticancer therapy

JM Han, HJ Jung - International journal of molecular sciences, 2022 - mdpi.com
Cyclophilin A (CypA), which has peptidyl–prolyl cis-trans isomerase (PPIase) activity,
regulates multiple functions of cells by binding to its extracellular receptor CD147. The …

Potential role of cyclophilin A in regulating cytokine secretion

FU Dawar, Y Xiong, MNK Khattak, J Li… - Journal of leukocyte …, 2017 - academic.oup.com
Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and
multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA …

PROTAC targeting cyclophilin A controls virus-induced cytokine storm

H Li, W Yang, H Li, X Bai, H Zhang, W Fan, W Liu… - Iscience, 2023 - cell.com
Cytokine storms caused by viruses are associated with elevated cytokine levels and
uncontrolled inflammatory responses that can lead to acute respiratory distress syndrome …

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

W Liu, J Li, W Zheng, Y Shang, Z Zhao, S Wang, Y Bi… - elife, 2017 - elifesciences.org
RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I
interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A …

Enhanced proliferation of Ly6C+ monocytes/macrophages contributes to chronic inflammation in skin wounds of diabetic mice

J Pang, M Maienschein-Cline, TJ Koh - The Journal of Immunology, 2021 - journals.aai.org
Diabetic wounds are characterized by persistent accumulation of proinflammatory
monocytes (Mo)/macrophages (MΦ) and impaired healing. However, the mechanisms …