Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
Symbionts and gene drive: two strategies to combat vector-borne disease
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …
technologies for controlling vector-borne pathogen transmission. These technologies …
CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii
AK Yadav, C Butler, A Yamamoto… - Proceedings of the …, 2023 - National Acad Sciences
Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance
Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …
specific target sites in a genome and bias their inheritance. Such gene drives can be …
Inherently confinable split-drive systems in Drosophila
CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …
Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
Applying genetic technologies to combat infectious diseases in aquaculture
NA Robinson, D Robledo, L Sveen… - Reviews in …, 2023 - Wiley Online Library
Disease and parasitism cause major welfare, environmental and economic concerns for
global aquaculture. In this review, we examine the status and potential of technologies that …
global aquaculture. In this review, we examine the status and potential of technologies that …
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of
populations with CRISPR homing gene drives. One proposed solution is using multiple …
populations with CRISPR homing gene drives. One proposed solution is using multiple …
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …