[HTML][HTML] An ethical framework for human embryology with embryo models

NC Rivron, AM Arias, MF Pera, N Moris, HI M'hamdi - Cell, 2023 - cell.com
A human embryo's legal definition and its entitlement to protection vary greatly worldwide.
Recently, human pluripotent stem cells have been used to form in vitro models of early …

Early human embryonic development: Blastocyst formation to gastrulation

J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature

AS Iltis, G Koster, E Reeves, KRW Matthews - Stem Cell Research & …, 2023 - Springer
Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

Sculpting with stem cells: how models of embryo development take shape

JV Veenvliet, PF Lenne, DA Turner, I Nachman… - …, 2021 - journals.biologists.com
During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

'Ceci n'est pas un embryon?'The ethics of human embryo model research

N de Graeff, L De Proost, M Munsie - Nature methods, 2023 - nature.com
‘Ceci n’est pas un embryon?’ The ethics of human embryo model research | Nature Methods
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

Carnegie in 4D? Stem-cell-based models of human embryo development

B Sozen, D Conkar, JV Veenvliet - Seminars in cell & developmental …, 2022 - Elsevier
How cells build embryos is still a major mystery. Many unresolved questions require the
study of the processes that pattern and shape the embryo in live specimens, in toto, across …

Autonomy in the development of stem cell-derived embryoids: sprouting blastocyst-like cysts, and ethical implications

HW Denker - Cells, 2021 - mdpi.com
The experimental production of complex structures resembling mammalian embryos (eg,
blastoids, gastruloids) from pluripotent stem cells in vitro has become a booming research …

Embryoids, models, embryos? We need to take a new look at legal norms concerning the beginning of organismic development

HW Denker - Molecular Human Reproduction, 2024 - academic.oup.com
The recent progress in research on embryo-like structures (ELS) derived in vitro from
pluripotent stem cells is impressive (Amadei et al., 2022; Rossant and Tam, 2022; Tarazi et …

Embryoid research calls for reassessment of legal regulations

M Hengstschläger, M Rosner - Stem cell research & therapy, 2021 - Springer
It is known that in countries, in which basic research on human embryos is in fact prohibited
by law, working with imported human embryonic stem cells (hESCs) can still be permitted …

[HTML][HTML] Current Status of Synthetic Mammalian Embryo Models

H Kim, E Kim - International Journal of Molecular Sciences, 2024 - mdpi.com
Advances in three-dimensional culture technologies have facilitated the development of
synthetic embryo models, such as blastoids, through the co-culturing of diverse stem cell …