Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells.
Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication …

Despite the recent advances in cancer research and treatment, gastrointestinal (GI) cancers
remain the most common deadly disease worldwide. The aberrant DNA replication serves …

Comprehensive proteome quantification is crucial for a better understanding of underlying
mechanisms of diseases. Liquid chromatography mass spectrometry (LC-MS) has become …

It has long been known that males are more susceptible than females to hepatocellular
carcinoma (HCC), but the reason remains elusive. In this study, we investigated the …

Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit
alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte …

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional
Chinese medicine for centuries. Several studies have highlighted its therapeutic potential for …

Background Gliomas are the most common type of all central nervous system tumors. Almost
all patients diagnosed with these tumors have a poor prognostic outcome. We aimed to …

DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes
correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and …

Current histoprognostic parameters and prognostic scores used in paragangliomas and
pheochromocytomas do not adequately predict the risk of metastastic progression and …

The mechanisms of self-renewal and pluripotency maintenance of human pluripotent stem
cells (hPSCs) have not been fully elucidated, especially for the role of those poorly …