Premature infants are exposed to increased generation of reactive oxygen species, and on
the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient …

In response to infectious and, in some instances, noninfectious insults, the affected
tissues/cells of the host undergo inflammation. However, uncontrolled inflammation could be …

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Preeclampsia (PE) is characterized by disturbed extravillous trophoblast migration toward
uterine spiral arteries leading to increased uteroplacental vascular resistance and by …

Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn -
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During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …

The aetiology of many gestational disorders is still unknown. However, insufficient trans-
placental nutrient and oxygen transfer due to abnormal placentation is characteristic of …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Pulmonary vascular disease can be defined as either a disease affecting the pulmonary
capillaries and pulmonary arterioles, termed pulmonary arterial hypertension, or a disease …

When the normal cardiopulmonary transition fails to occur, the result is persistent pulmonary
hypertension of the newborn. Severe persistent pulmonary hypertension of the newborn is …