Cell population heterogeneity and evolution towards drug resistance in cancer: biological and mathematical assessment, theoretical treatment optimisation
Background Drug-induced drug resistance in cancer has been attributed to diverse
biological mechanisms at the individual cell or cell population scale, relying on …
biological mechanisms at the individual cell or cell population scale, relying on …
Bocop-A collection of examples
FJ Bonnans, P Martinon, V Grélard - 2012 - inria.hal.science
BOCOP - A collection of examples Page 1 ISSN 0249-6399 ISRN INRIA/RR--8053--FR+ENG
RESEARCH REPORT N 8053 September 2012 Project-Teams Commands BOCOP - A …
RESEARCH REPORT N 8053 September 2012 Project-Teams Commands BOCOP - A …
Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations
Background A thorough understanding of the ecological and evolutionary mechanisms that
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …
Blood cell dynamics: half of a century of modelling
L Pujo-Menjouet - Mathematical Modelling of Natural …, 2016 - mmnp-journal.org
The objective of this paper is to give a review of the main works dealing with mathematical
modeling of blood cell formation, disorders and treatments within the past fifty years. From …
modeling of blood cell formation, disorders and treatments within the past fifty years. From …
Noether currents for higher-order variational problems of Herglotz type with time delay
We study, from an optimal control perspective, Noether currents for higher-order problems of
Herglotz type with time delay. Main result provides new Noether currents for such …
Herglotz type with time delay. Main result provides new Noether currents for such …
Cancer cells population control in a delayed-model of a leukemic patient using the combination of the eligibility traces algorithm and neural networks
E Kalhor, A Noori, G Noori - … Journal of Machine Learning and Cybernetics, 2021 - Springer
The main purpose of this paper is to provide a solution, through which one can efficiently
reduce the population of cancer cells by injecting the lowest dose of the drug; therefore …
reduce the population of cancer cells by injecting the lowest dose of the drug; therefore …
Optimal control of state constrained age-structured problems
JF Bonnans, J Gianatti - SIAM Journal on Control and Optimization, 2020 - SIAM
The aim of this work is to study an optimal control problem with state constraints where the
state is given by an age-structured, abstract parabolic differential equation. We prove the …
state is given by an age-structured, abstract parabolic differential equation. We prove the …
Equations à retard et modèles de dynamiques de populations cellulaires
F Crauste - 2014 - inria.hal.science
A travers deux chapitres, je présente mon activité de recherche depuis 2006, date de mon
recrutement au CNRS. Celle-ci a concerné la modélisation et l'étude mathématique de …
recrutement au CNRS. Celle-ci a concerné la modélisation et l'étude mathématique de …
An intelligent control strategy for cancer cells reduction in patients with chronic myelogenous leukaemia using the reinforcement learning and considering side effects …
Abstract Chronic Myelogenous Leukaemia (CML) is a haematopoietic stem cells disease
with complex dynamical behaviour. One of the effective factors in treating patients is to …
with complex dynamical behaviour. One of the effective factors in treating patients is to …
Evitement de conflits aériens par une régulation subliminale en vitesse: modélisation & résolution via le contrôle optimal
L Cellier - 2015 - theses.hal.science
À travers une approche de contrôle optimal, cette thèse de doctorat propose une étude des
modèles et des techniques de résolution dans un domaine d'application propre à la gestion …
modèles et des techniques de résolution dans un domaine d'application propre à la gestion …