Microfluidic Platform Enables Shearless Aerosolization of Lipid Nanoparticles for mRNA Inhalation

J Kim, A Jozić, E Bloom, B Jones, M Marra… - ACS …, 2024 - ACS Publications
Leveraging the extensive surface area of the lungs for gene therapy, the inhalation route
offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh …

Targeted delivery of type I TGF-β receptor-mimicking peptide to fibrotic kidney for improving kidney fibrosis therapy via enhancing the inhibition of TGF-β1/Smad and …

X Wang, X Liu, L Xu, Y Li, B Zheng, C Xia… - International …, 2024 - Elsevier
Renal fibrosis is a representative pathological feature of various chronic kidney diseases,
and efficient treatment is needed. Interstitial myofibroblasts are a key driver of kidney …

Latest Delivery Advancements of Lipid Nanoparticles for Cancer Treatment

S Chauhan, K Nagpal - ASSAY and Drug Development …, 2024 - liebertpub.com
As one of the primary causes of illness and death globally, cancer demands novel and
potent treatment approaches, which is why lipid nanoparticles (LNPs) have gained attention …

Optimized Colitis Model with Peak Colonic Macrophage Infiltration

H Qian - 2024 - jscholarship.library.jhu.edu
Although the etiology of inflammatory bowel disease (IBD), an increasingly popular disease
of chronic intestinal inflammation, has not been fully understood, macrophage has been …