The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most
extensively exploited in cells of the immune system. Among these properties are NF-kappa …

A role for redox regulation In activation of the NF-xB transcription factor was suggested by
the observation that DNA binding activity of free protein, but not preformed DNA-proteln …

Abstract Poly (ADP‐ribose) polymerase‐1 is a nuclear DNA‐binding protein that participates
in the DNA base excision repair pathway in response to genotoxic stress in mammalian …

Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …

Publisher Summary This chapter highlights NF-кB/Rel protein complex. Associations of the
binding and regulatory subunits of NF-кB operate at the center of a variety of different signal …

It has been suggested that the NF-κB transcription factor family may mediate expression of
the gene encoding the cytokine-inducible form of nitric oxide synthase (iNOS). To establish if …

Vertebrates respond to infection through a combination of adaptive or acquired immunity
and innate or natural immunity. The principal feature of acquired immunity is the generation …

NF-kB is an inducible transcription factor present in many cell types in a latent cytoplasmic
form. So far, only immune cells including mature B cells, thymocytes, and adherent …