Cancer-associated cachexia—understanding the tumour macroenvironment and microenvironment to improve management

JM Argilés, FJ López-Soriano, B Stemmler… - Nature Reviews …, 2023 - nature.com
Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

AM Thomas, M Fidelle, B Routy, G Kroemer… - Nature reviews Clinical …, 2023 - nature.com
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

Gut microbes and muscle function: can probiotics make our muscles stronger?

M Giron, M Thomas, D Dardevet… - Journal of cachexia …, 2022 - Wiley Online Library
Evidence suggests that gut microbiota composition and diversity can be a determinant of
skeletal muscle metabolism and functionality. This is true in catabolic (sarcopenia and …

[HTML][HTML] Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Z Zhang, H Tang, P Chen, H Xie, Y Tao - Signal transduction and …, 2019 - nature.com
The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

Inter-tissue communication in cancer cachexia

JM Argilés, B Stemmler, FJ López-Soriano… - Nature Reviews …, 2019 - nature.com
Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis

GJ Grosicki, RA Fielding, MS Lustgarten - Calcified tissue international, 2018 - Springer
Skeletal muscle is a highly plastic tissue that plays a central role in human health and
disease. Aging is associated with a decrease in muscle mass and function (sarcopenia) that …

Gut microbiota and short‐chain fatty acid alterations in cachectic cancer patients

J Ubachs, J Ziemons, Z Soons… - Journal of cachexia …, 2021 - Wiley Online Library
Background Cancer cachexia is characterized by a negative energy balance, muscle and
adipose tissue wasting, insulin resistance, and systemic inflammation. Because of its strong …

[HTML][HTML] Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder

S Leclercq, T Le Roy, S Furgiuele, V Coste, LB Bindels… - Cell Reports, 2020 - cell.com
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and
social impairments. The gut microbiota has been recently shown to regulate brain functions …

[HTML][HTML] Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

V Rausch, V Sala, F Penna, PE Porporato, A Ghigo - Oncogenesis, 2021 - nature.com
Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

[HTML][HTML] Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans

S Hiel, LB Bindels, BD Pachikian, G Kalala… - The American journal of …, 2019 - Elsevier
ABSTRACT Background Inulin-type fructans (ITFs) are a type of fermentable dietary fiber
that can confer beneficial health effects through changes in the gut microbiota. However …