This book presents a unified and up-to-date introduction to ROC methodologies, covering
both diagnosis (classification) and prediction. The emphasis is on the conceptual …

OBJECTIVES: The Texas Hepatocellular Carcinoma Consortium cohort study investigates
risk factors of hepatocellular carcinoma (HCC) and biomarkers for early HCC detection in …

Hospital-acquired pressure injury is difficult to identify in the early stage, accompanied with
increased morbidity but considered to be preventable. For helping the nurses to monitor the …

Pancreatic ductal adenocarcinoma (PDAC) is the most deadly cancer and currently there is
strong clinical interest in novel biomarkers that contribute to its early detection. Assessing …

The performance of individual biomarkers in discriminating between two groups, typically
the healthy and the diseased, may be limited. Thus, there is interest in developing statistical …

Tuberculosis (TB) studies often involve four different states under consideration,
namely,“healthy,”“latent infection,”“pulmonary active disease,” and “extra‐pulmonary active …

Currently, there is global interest in deriving new promising cancer biomarkers that could
complement or substitute the conventional ones. Clinical decisions can often be based on …

This article considers a setting in diagnostic studies (or biomarker study) which involves a
healthy class and a diseased class and the latter consists of several subclasses. The …

In a matched‐pair study, when outcomes of two diagnostic tests are ordinal/continuous, the
difference between two correlated areas under ROC curves (AUCs) is usually used to …

Background Fluid resuscitation is a cornerstone of minimizing morbidity and mortality in
critically ill patients, but the techniques for predicting fluid responsiveness is still a matter of …