Effect of circadian clock disruption on type 2 diabetes

HT Tran, T Kondo, A Ashry, Y Fu, H Okawa… - Frontiers in …, 2024 - frontiersin.org
Introduction Type 2 diabetes (T2D) is the predominant form of diabetes mellitus and is
among the leading causes of death with an increasing prevalence worldwide. However, the …

Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology

E Murgo, T Colangelo, MM Bellet, F Malatesta… - Biology, 2023 - mdpi.com
Simple Summary NPAS2, short for Neuronal PAS Domain Protein 2, is a transcription factor
involved in regulating the circadian rhythms and sleep–wake cycles in mammals, including …

Effective electrical stimulation by a Poly (l-lactic acid)/Vitamin B2-Based piezoelectric generator promotes wound healing

Z Zhang, L Wang, Q Zhang, H Li, Y Xiang… - European Polymer …, 2023 - Elsevier
Chronic wounds pose an increasing burden not only to patients, but also to the health
system. Wound repair requires the timely and orderly migration of fibroblasts to the wound …

Downregulation of a potential therapeutic target NPAS2, regulated by p53, alleviates pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via …

Y Chen, Z He, B Zhao, R Zheng - Cellular Signalling, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease and a severe form of
pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) of alveolar epithelial cells is …

A novel lncRNA FPASL regulates fibroblast proliferation via the PI3K/AKT and MAPK signaling pathways in hypertrophic scar: FPASL regulates hypertrophic scar via …

F Ma, J Shen, H Zhang, Z Zhang… - Acta Biochimica et …, 2022 - pmc.ncbi.nlm.nih.gov
Hypertrophic scar is a problem for numerous patients, especially after burns, and is
characterized by increased fibroblast proliferation and collagen deposition. Increasing …

[HTML][HTML] In vitro and in vivo assessment of a non-animal sourced chitosan scaffold loaded with xeno-free umbilical cord mesenchymal stromal cells cultured under …

A Di Nubila, MN Doulgkeroglou, M Gurdal… - Biomaterials and …, 2024 - Elsevier
There is an increasing demand to not only accelerate the development of advanced therapy
tissue engineered medicines, but to also eliminate xenogeneic materials from their …

The adipose‐derived stem cell peptide ADSCP2 alleviates hypertrophic scar fibrosis via binding with pyruvate carboxylase and remodeling the metabolic landscape

J Li, Y Yin, J Zou, E Zhang, Q Li, L Chen… - Acta Physiologica, 2023 - Wiley Online Library
Aim The purpose of this study was to investigate the function and mechanism of a novel
peptide derived from adipose‐derived stem cell‐conditioned medium (ADSC‐CM). Methods …

Therapeutic potential of adipose stem cell-derived conditioned medium on scar contraction model

Y Imai, N Mori, Y Nihashi, Y Kumagai, Y Shibuya… - Biomedicines, 2022 - mdpi.com
Scars are composed of stiff collagen fibers, which contract strongly owing to the action of
myofibroblasts. To explore the substances that modulate scar contracture, the fibroblast …

[HTML][HTML] Folium crataegi boosts skin regeneration for burn injury in rats through multiple ways

Z Deng, L Zhao, X Li, CY Wang, Y Zhou, M Li… - Biomedicine & …, 2023 - Elsevier
Appropriate topical dressings for burn treatments are important to accelerate skin wound
recovery and prevent external infections. This study aimed to evaluate the effect and …

Therapeutic Potential of Adipose-Derived Stem Cell-Conditioned Medium and Extracellular Vesicles in an In Vitro Radiation-Induced Skin Injury Model

Z Lin, Y Shibuya, Y Imai, J Oshima, M Sasaki… - International Journal of …, 2023 - mdpi.com
Radiotherapy (RT) is one of three major treatments for malignant tumors, and one of its most
common side effects is skin and soft tissue injury. However, the treatment of these remains …