Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

[HTML][HTML] Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro …

SY Huang, T Witzel, B Keil, A Scholz, M Davids, P Dietz… - NeuroImage, 2021 - Elsevier
The first phase of the Human Connectome Project pioneered advances in MRI technology
for mapping the macroscopic structural connections of the living human brain through the …

Oscillating gradient spin‐echo (OGSE) diffusion tensor imaging of the human brain

CA Baron, C Beaulieu - Magnetic resonance in medicine, 2014 - Wiley Online Library
Purpose The dependence of diffusion tensor imaging (DTI) eigenvalues and fractional
anisotropy (FA) on short diffusion times was investigated using oscillating gradient spin echo …

PGSE, OGSE, and sensitivity to axon diameter in diffusion MRI: Insight from a simulation study

I Drobnjak, H Zhang, A Ianuş, E Kaden… - Magnetic resonance …, 2016 - Wiley Online Library
Purpose To identify optimal pulsed gradient spin‐echo (PGSE) and oscillating gradient spin‐
echo (OGSE) sequence settings for maximizing sensitivity to axon diameter in idealized and …

[HTML][HTML] The dot-compartment revealed? Diffusion MRI with ultra-strong gradients and spherical tensor encoding in the living human brain

CMW Tax, F Szczepankiewicz, M Nilsson, DK Jones - Neuroimage, 2020 - Elsevier
The so-called “dot-compartment” is conjectured in diffusion MRI to represent small spherical
spaces, such as cell bodies, in which the diffusion is restricted in all directions. Previous …

In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy

X Jiang, H Li, J Xie, ET McKinley, P Zhao… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose A temporal diffusion MRI spectroscopy based approach has been developed to
quantify cancer cell size and density in vivo. Methods A novel imaging microstructural …

Magnetic resonance imaging of mean cell size in human breast tumors

J Xu, X Jiang, H Li, LR Arlinghaus… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose Cell size is a fundamental characteristic of all tissues, and changes in cell size in
cancer reflect tumor status and response to treatments, such as apoptosis and cell‐cycle …

Diffusion MRI with pulsed and free gradient waveforms: effects of restricted diffusion and exchange

A Chakwizira, CF Westin, J Brabec, S Lasič… - NMR in …, 2023 - Wiley Online Library
Monitoring time dependence with diffusion MRI yields observables sensitive to compartment
sizes (restricted diffusion) and membrane permeability (water exchange). However …

[HTML][HTML] Correlation Tensor MRI deciphers underlying kurtosis sources in stroke

R Alves, RN Henriques, L Kerkelä, C Chavarrías… - Neuroimage, 2022 - Elsevier
Noninvasively detecting and characterizing modulations in cellular scale micro-architecture
remains a desideratum for contemporary neuroimaging. Diffusion MRI (dMRI) has become …

[HTML][HTML] Frequency-dependent diffusion kurtosis imaging in the human brain using an oscillating gradient spin echo sequence and a high-performance head-only …

E Dai, A Zhu, GK Yang, K Quah, ET Tan, E Fiveland… - NeuroImage, 2023 - Elsevier
Measuring the time/frequency dependence of diffusion MRI is a promising approach to
distinguish between the effects of different tissue microenvironments, such as membrane …