Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …

Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Some patients prescribed flucloxacillin (~ 0.01%) develop drug‐induced liver injury (DILI).
HLA‐B* 57: 01 is an established genetic risk factor for flucloxacillin DILI. To consolidate this …

Clinical vignette A 21-year old woman was admitted to hospital with a two-week history of
painless jaundice, fatigue and anorexia having previously been fit and well. One month prior …

Drug‐induced liver injury (DILI) is a complication of treatment with antituberculosis (TB)
drugs, especially in isoniazid (INH)‐containing regimens. To investigate genetic risk factors …

Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Genetic
factors predispose to many ADRs, affecting susceptibility to both type A and type B reactions …

Abstract The African Pharmacogenomics Consortium (APC) was formally launched on the
6th September 2018. This white paper outlines its vision, and objectives towards addressing …

Introduction: Idiosyncratic drug-induced liver injury (DILI) is a challenging condition with
widespread implications. The underlying mechanism of DILI is not yet fully elucidated, but …

Introduction Dual diethylcarbamazine and albendazole (DA) therapy is the standard mass
drug administration (MDA) regimen for lymphatic filariasis in Kenya. Following the recent …

Adverse drug reactions are an important cause of morbidity and mortality and constitute the
leading reason of drug withdrawal from the market. Besides classical reactions that are …