Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo …

Diabetes mellitus is an extremely prevalent endocrine disease and a major global public
health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and …

Diabetic microvascular complications have been considered to be mediated by a glucose-
driven increase in mitochondrial superoxide anion production. Here, we report that …

Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

Diabetic kidney disease (DKD) occurs in 25%-40% of patients with diabetes. Given the dual
problems of a significant risk of progression from DKD to end-stage renal disease (ESRD) …

As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …