Next-generation cancer organoids
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …
cancer heterogeneity and its implications for personalized medicine. These advancements …
[PDF][PDF] 2D and 3D cell cultures–a comparison of different types of cancer cell cultures
M Kapałczyńska, T Kolenda, W Przybyła… - Archives of medical …, 2018 - termedia.pl
Cell culture is a widely used in vitro tool for improving our understanding of cell biology,
tissue morphology, and mechanisms of diseases, drug action, protein production and the …
tissue morphology, and mechanisms of diseases, drug action, protein production and the …
Extracellular vesicle and particle biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …
detection. We investigated the proteomic profile of extracellular vesicles and particles …
[HTML][HTML] An embryonic diapause-like adaptation with suppressed Myc activity enables tumor treatment persistence
E Dhimolea, R de Matos Simoes, D Kansara… - Cancer cell, 2021 - cell.com
Treatment-persistent residual tumors impede curative cancer therapy. To understand this
cancer cell state we generated models of treatment persistence that simulate the residual …
cancer cell state we generated models of treatment persistence that simulate the residual …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Tumour exosome integrins determine organotropic metastasis
A Hoshino, B Costa-Silva, TL Shen, G Rodrigues… - Nature, 2015 - nature.com
Abstract Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …
Organoids: a historical perspective of thinking in three dimensions
M Simian, MJ Bissell - Journal of Cell Biology, 2017 - rupress.org
In the last ten years, there has been a dramatic surge in the number of publications where
single or groups of cells are grown in substrata that have elements of basement membrane …
single or groups of cells are grown in substrata that have elements of basement membrane …
Advances in multicellular spheroids formation
Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …
The extracellular matrix modulates the hallmarks of cancer
The extracellular matrix regulates tissue development and homeostasis, and its
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …
dysregulation contributes to neoplastic progression. The extracellular matrix serves not only …
Liver organoids: from basic research to therapeutic applications
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …
dish. While mouse models and cell lines have furthered our understanding of liver biology …