Neurosteroid actions in memory and neurologic/neuropsychiatric disorders

MH Ratner, V Kumaresan, DH Farb - Frontiers in endocrinology, 2019 - frontiersin.org
Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric
disorders; however, the basic underlying mechanisms of memory and altered states of …

Androgen therapy in neurodegenerative diseases

VE Bianchi, L Rizzi, E Bresciani… - Journal of the …, 2020 - academic.oup.com
Neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD),
multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington disease, are …

Developmental effects of androgens in the human brain

TV Nguyen - Journal of Neuroendocrinology, 2018 - Wiley Online Library
Neuroendocrine theories of brain development posit that androgens play a crucial role in
sex‐specific cortical growth, although little is known about the differential effects of …

Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development

TV Nguyen, M Wu, J Lew, MD Albaugh… - …, 2017 - Elsevier
Existing studies suggest that dehydroepiandrosterone (DHEA) may be important for human
brain development and cognition. For example, molecular studies have hinted at the critical …

[HTML][HTML] Young adult Swedish patients with autoimmune Addison's disease report difficulties with executive functions in daily life despite overall good cognitive …

A Van't Westeinde, S Ström, T Hirvikoski… - …, 2022 - Elsevier
Objectives Sub-optimal replacement of glucocorticoids (GC) in autoimmune Addison's
disease (AAD) may affect cognitive functioning. The present study therefore sought to …

Sex‐specific contribution of DHEA‐cortisol ratio to prefrontal‐hippocampal structural development, cognitive abilities and personality traits

NAI Farooqi, M Scotti, A Yu, J Lew… - Journal of …, 2019 - Wiley Online Library
Although dehydroepiandrosterone (DHEA) may exert neuroprotective effects in the
developing brain, prolonged or excessive elevations in cortisol may exert neurotoxic effects …

Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood

MJAM Braamskamp, DM Kusters, A Wiegman, HJ Avis… - Atherosclerosis, 2015 - Elsevier
Objective Statins are currently the preferred pharmacological therapy in children with familial
hypercholesterolemia (FH) with the aim to prevent premature cardiovascular disease (CVD) …

The steroid metabolite 16 (β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1

J Neunzig, M Milhim, L Schiffer, Y Khatri, J Zapp… - The Journal of Steroid …, 2017 - Elsevier
Abstract The 21-hydroxylase (CYP21A2) is a steroidogenic enzyme crucial for the synthesis
of mineralo-and glucocorticoids. It is described to convert progesterone as well as 17-OH …

[HTML][HTML] Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing—A behavioral and electrophysiological approach

S do Vale, L Selinger, JM Martins, M Bicho… - Hormones and …, 2015 - Elsevier
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may have
mood enhancement effects: higher DHEAS concentrations and DHEA/cortisol ratio have …

Dehydroepiandrosterone and dehydroepiandrosterone-sulfate and emotional processing

S do Vale, C Escera - Vitamins and hormones, 2018 - Elsevier
Steroid hormones are important regulators of brain development, physiological function, and
behavior. Among them, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone …