Mechanism of action of ribosomally synthesized and post-translationally modified peptides
C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …
product class that has undergone significant expansion due to the rapid growth in genome …
New developments in RiPP discovery, enzymology and engineering
M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
Mechanistic understanding of lanthipeptide biosynthetic enzymes
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …
New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products
MA Ortega, WA Van Der Donk - Cell chemical biology, 2016 - cell.com
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique …
group of structurally diverse natural products. Their biological activities and unique …
Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
MC Walker, SM Eslami, KJ Hetrick, SE Ackenhusen… - BMC genomics, 2020 - Springer
Background Lanthipeptides belong to the ribosomally synthesized and post-translationally
modified peptide group of natural products and have a variety of biological activities ranging …
modified peptide group of natural products and have a variety of biological activities ranging …
Cacaoidin, first member of the new lanthidin RiPP family
FJ Ortiz‐López, D Carretero‐Molina… - Angewandte Chemie …, 2020 - Wiley Online Library
Lantibiotics are ribosomally synthesized and post‐translationally modified peptides (RiPPs)
characterized by the presence of lanthionine or methyllanthionine rings and their …
characterized by the presence of lanthionine or methyllanthionine rings and their …
Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks
Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …
Discovering new bioactive molecules from microbial sources
There is an increased need for new drug leads to treat diseases in humans, animals and
plants. A dramatic example is represented by the need for novel and more effective …
plants. A dramatic example is represented by the need for novel and more effective …
Therapeutic application of lantibiotics and other lanthipeptides: old and new findings
Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides, with
modifications that are incorporated during biosynthesis by dedicated enzymes. Various …
modifications that are incorporated during biosynthesis by dedicated enzymes. Various …
Bioengineering lantibiotics for therapeutic success
Several examples of highly modified antimicrobial peptides have been described. While
many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents …
many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents …