β-and γ-cytoplasmic actins are ubiquitously expressed in every cell type and are nearly
identical at the amino acid level but play vastly different roles in vivo. Their essential roles in …

The interactions at the graft–tissue interfaces are critical for the results of engraftments post-
implantation. To improve the success rate of the implantations, as well as the quality of the …

Highlights•Simulations can help explain & test models of complex multiscale biological
processes•Model interoperation is made difficult by the diversity of approaches and …

Mitotic spindle assembly is crucial for chromosome segregation and relies on bundles of
microtubules that extend from the poles and overlap in the middle. However, how these …

Mechanochemical simulations of actomyosin networks are traditionally based on one-
dimensional models of actin filaments having zero width. Here, and in the follow up paper …

The plasma membrane defines the shape of the cell and plays an indispensable role in
bridging intra-and extracellular environments. Mechanochemical interactions between …

Several actin-binding proteins (ABPs) phase separate to form condensates capable of
curating the actin network shapes. Here, we use computational modeling to understand the …

Actomyosin networks give cells the ability to move and divide. These networks contract and
expand while being driven by active energy-consuming processes such as motor protein …

The homeostasis of extracellular matrix (ECM) and actin dynamics in the trabecular
meshwork (TM) outflow pathway plays a critical role in intraocular pressure (IOP) regulation …

Epithelial-mesenchymal plasticity (EMP) underlies embryonic development, wound healing,
and cancer metastasis and fibrosis. Cancer cells exhibiting EMP often have more …