Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the
colonic host-microbe interactions that help maintain gut homeostasis. However, the precise …

Ulcerative colitis (UC) is an inflammatory bowel disease with complex pathogenesis, which
is affected by genetic factors, intestinal immune status and intestinal microbial homeostasis …

Regardless of progress in therapy management which are developed for colon cancer (CC),
it remains the third most common cause of mortality due to cancers around the world …

Much remains unknown about how the intestinal microbiome interfaces with the protective
intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can …

Objective Serrated lesions such as sessile serrated adenomas or polyps (SSA/Ps) are
important colorectal cancer precursors, but aetiological factors for these lesions are largely …

Microbiome, considered as the “second genome” of the host, is altered in type 1 diabetes
mellitus (T1DM) patients to a state of dysbiosis. Mesenchymal stem cell (MSC) …

Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic …

Mucus reduces friction between epithelial surfaces by providing lubrication in the boundary
and mixed regime. Mucins, the main macromolecule, are heavily glycosylated proteins that …

The modification of adenosine to inosine at the wobble position (I34) of tRNA anticodons is
an abundant and essential feature of eukaryotic tRNAs. The expansion of inosine-containing …

Mucins are the main macrocomponents of the mucus layer that protects the digestive tract
from pathogens. Fucosylation of mucins increases mucus viscoelasticity and its resistance to …