LPS versus Poly I: C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring

M Bao, N Hofsink, T Plösch - American Journal of …, 2022 - journals.physiology.org
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to
human health. However, the long-term health consequences are largely unknown and …

Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations

JD Reiss, LS Peterson, SN Nesamoney, AL Chang… - Experimental …, 2022 - Elsevier
Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …

COVID‐19 in pregnancy: Placental and neonatal involvement

E Prochaska, M Jang, I Burd - American journal of reproductive …, 2020 - Wiley Online Library
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
has caused over 12 million infections and more than 550 000 deaths. 1 Morbidity and …

“Females are not just 'protected'males”: Sex-specific vulnerabilities in placenta and brain after prenatal immune disruption

AE Braun, PA Carpentier, BA Babineau, AR Narayan… - eneuro, 2019 - eneuro.org
Current perceptions of genetic and environmental vulnerabilities in the developing fetus are
biased toward male outcomes. An argument is made that males are more vulnerable to …

Formulating a meaningful and comprehensive placental phenotypic classification

AA Freedman, LS Keenan-Devlin… - Pediatric and …, 2021 - journals.sagepub.com
Introduction While many placental lesions have been identified and defined, the significance
of multiple overlapping lesions has not been addressed. The purpose of our analysis was to …

Gene-environment interactions during the first thousand days influence childhood neurological diagnosis

MS Scher - Seminars in Pediatric Neurology, 2022 - Elsevier
Gene-environment (G x E) interactions significantly influence neurologic outcomes. The
maternal-placental-fetal (MPF) triad, neonate, or child less than 2 years may first exhibit …

Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation‐induced oxidative stress in a mouse model

JY Lee, S Li, NE Shin, Q Na, J Dong… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin has been shown to reduce oxidative stress and mitigate hypercoagulability. We
hypothesized that maternally administered melatonin may reduce placental oxidative stress …

Placental macrophages demonstrate sex-specific response to intrauterine inflammation and may serve as a marker of perinatal neuroinflammation

Q Na, A Chudnovets, J Liu, JY Lee, J Dong… - Journal of Reproductive …, 2021 - Elsevier
Preterm birth (PTB) is considered to be one of the most frequent causes of neonatal death.
Prompt and effective measures to predict adverse fetal outcome following PTB are urgently …

[HTML][HTML] Hearing screening test in neonates born to COVID-19–positive mothers

A Goulioumis, M Angelopoulou, K Kourelis… - European Journal of …, 2023 - Springer
Abstract SARS-CoV-2, the responsible virus for the COVID-19 pandemic, has demonstrated
neurotropic properties indicated by cases presenting with auditory and vestibular system …

Dose‐dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy

A Chudnovets, J Lei, Q Na, J Dong… - American Journal of …, 2020 - Wiley Online Library
Problem Systemic maternal inflammation is associated with adverse neonatal sequelae. We
tested the hypothesis that IL‐1β is a key inflammatory regulator of adverse pregnancy …