[HTML][HTML] ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification

CW Wang, HC Chuang, TH Tan - Journal of Biomedical Science, 2023 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-
angiotensin system, provides protection against several chronic diseases. Besides chronic …

[HTML][HTML] Mechanisms leading to gut dysbiosis in COVID-19: current evidence and uncertainties based on adverse outcome pathways

LA Clerbaux, J Filipovska, A Muñoz, M Petrillo… - Journal of clinical …, 2022 - mdpi.com
Alteration in gut microbiota has been associated with COVID-19. However, the underlying
mechanisms remain poorly understood. Here, we outlined three potential interconnected …

[HTML][HTML] COVID-19: biologic and immunosuppressive therapy in gastroenterology and hepatology

MF Neurath - Nature Reviews Gastroenterology & Hepatology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global health
crisis causing major challenges for clinical care in patients with gastrointestinal diseases …

Bioadhesive microcarriers encapsulated with IL‐27 high expressive MSC extracellular vesicles for inflammatory bowel disease treatment

M Nie, D Huang, G Chen, Y Zhao, L Sun - Advanced Science, 2023 - Wiley Online Library
Mesenchymal stem cell (MSC) therapy is a promising candidate for inflammatory bowel
disease (IBD) treatment, while overcoming the limitations of naive seeding cells function and …

Bile acids and bile acid activated receptors in the treatment of Covid-19

S Fiorucci, G Urbani, M Biagioli, V Sepe… - Biochemical …, 2023 - Elsevier
Since its first outbreak in 2020, the pandemic caused by the Severe Acute Respiratory
Syndrome-Coronavirus-2 (SARS-CoV-2) has caused the death of almost 7 million people …

Inflammatory bowel disease clinical activity is associated with COVID-19 severity especially in younger patients

A Ricciuto, CA Lamb, EI Benchimol… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Age is a major prognostic factor for COVID-19 outcomes. The
effect of inflammatory bowel disease [IBD] activity on COVID-19 is unclear. We examined the …

Immunology of bile acids regulated receptors

S Fiorucci, S Marchianò, G Urbani, C Di Giorgio… - Progress in Lipid …, 2024 - Elsevier
Bile acids are steroids generated at the interface of host and intestinal microbiota. While
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …

[HTML][HTML] Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection

KK Jang, ME Kaczmarek, S Dallari, YH Chen… - PLoS …, 2022 - journals.plos.org
Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly
variable for reasons that are not understood. In this study, we used intestinal organoid …

[HTML][HTML] Molecular insights into SARS-CoV2-induced alterations of the gut/brain axis

S Nataf, L Pays - International Journal of Molecular Sciences, 2021 - mdpi.com
For a yet unknown reason, a substantial share of patients suffering from COVID-19 develop
long-lasting neuropsychiatric symptoms ranging from cognitive deficits to mood disorders …

[HTML][HTML] Hypothesis: Emerging roles for aryl hydrocarbon receptor in orchestrating CoV-2-related inflammation

T Guarnieri - Cells, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the pathogenic agent
of Coronavirus-Induced Disease-2019 (COVID-19), a multi-organ syndrome which primarily …