Synthesis of theories on cellular powering, coherence, homeostasis and electro‐mechanics: Murburn concept and evolutionary perspectives

KM Manoj, L Jaeken - Journal of Cellular Physiology, 2023 - Wiley Online Library
If evolution was/is a fact, a simplified/unifying approach to explain cellular physiology is
warranted. Such a perspective should agree with the thermodynamic, kinetic, structural, and …

[HTML][HTML] Modulation of biomolecular phase behavior by metal ions

K Sołtys, A Tarczewska, D Bystranowska - Biochimica et Biophysica Acta …, 2023 - Elsevier
Liquid–liquid phase separation (LLPS) appears to be a newly appreciated aspect of the
cellular organization of biomolecules that leads to the formation of membraneless …

Na, K-ATPase: A murzyme facilitating thermodynamic equilibriums at the membrane-interface.

KM Manoj, DA Gideon, NM Bazhin… - Journal of Cellular …, 2022 - europepmc.org
The redox metabolic paradigm of murburn concept advocates that diffusible reactive species
(DRS, particularly oxygen-centric radicals) are mainstays of physiology, and not mere …

Proto-Neurons from Abiotic Polypeptides

P Mougkogiannis, A Adamatzky - Encyclopedia, 2024 - mdpi.com
To understand the origins of life, we must first gain a grasp of the unresolved emergence of
the first informational polymers and cell-like assemblies that developed into living systems …

Na, K-ATPase: Structure-distribution-mechanism versus physiological and evolutionary mandates

KM Manoj, B Nikolai, H Tamagawa, M Kavdia… - 2022 - osf.io
New techniques and elucidations in structural biology have enabled greater insights into the
functioning of proteins. Since its discovery in 1957 by Jens Skou, the membrane protein of …

Immobile Charges Play an Essential Role for Membrane Potential Generation

H Tamagawa, B Delalande - 2024 - preprints.org
The physiological mechanism of membrane potential generation relies on the passage of
mobile ions across the plasma membrane, which is selectively permeable to mobile ions …