Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Background A target AUC0-24/MIC ratio of 400 has been associated with its clinical success
when treating Staphylococcus aureus infections but is not currently supported by state-of-the …

Despite the development of novel antibiotics active against Gram-positive bacteria,
vancomycin generally remains the first treatment, although rapidly achieving concentrations …

Controversy continues regarding whether the presence of meticillin resistance increases
mortality risk in Staphylococcus aureus infections. In this study, we assessed the role of …

Background Artificial intelligence (AI) tools are more effective if accepted by clinicians. We
developed an AI-based clinical decision support system (CDSS) to facilitate vancomycin …

Intracellular pathogenic bacteria use immune cells as hosts for bacterial replication and
reinfection, leading to challenging systemic infections including peritonitis. The spread of …

Vancomycin is one of the “last-line” classes of antibiotics used in the treatment of life-
threatening infections caused by Gram-positive bacteria. Even though vancomycin was …

Objectives The objectives of this study were to characterize the population pharmacokinetics
of vancomycin in trauma patients and to propose dosing schemes to optimize therapy …

Despite the development of new agents with activity against Gram-positive bacteria,
vancomycin remains one of the primary antibiotics for critically ill septic patients. Because …

Topical and transdermal delivery of vancomycin hydrochloride (VH), a broad-spectrum
peptide antibiotic, is a challenge because of its high molecular weight (1485.7 Da) and …