The 1, 2-diamine moiety is an ubiquitous structural motif found in a wealth of natural
products, including non-proteinogenic amino acids and alkaloids, in pharmaceutical agents …

The epidemic of viral diseases is a global concern, mandating an urgent need of most
promising antivirals. Some of the viral diseases can be cured by approved antiviral drugs …

The kinetic resolution of 2‐aryl‐N‐tosylaziridines and the asymmetric desymmetrization of
meso‐N‐tosylaziridines by ring openings with various primary and secondary anilines, and …

Hepatitis C virus (HCV) infection is a major biomedical problem worldwide. Although new
direct antiviral agents (DAAs) have been developed for the treatment of chronic HCV …

Hepatitis C virus (HCV) genome replication is thought to occur in a membranous cellular
compartment derived from the endoplasmic reticulum (ER). The molecular mechanisms by …

NS5B is pivotal RNA dependent RNA polymerase (RdRp) of HCV and NS5B function
interfering halts the virus infective cycle. This work aimed to produce cell penetrable …

Hepatitis C virus (HCV) infects chronically 3% of the world population and the current
therapy against this pathogen is only partially effective. With the aim of developing novel …

Hepatitis C virus (HCV) infection is a major biomedical problem worldwide as it causes
severe liver disease in millions of humans around the world. Despite the recent approval of …

Replication of hepatitis C virus (HCV) is dependent on virus-encoded proteins and
numerous cellular factors. DDX3 is a well-known host cofactor of HCV replication. In this …

COVID-19 outbreak is a common respiratory tract infection in humans primarily caused by a
new type of virus SARS-CoV-2 (2019-nCoV) started in 2019 and spread quickly within the …