Reelin functions, mechanisms of action and signaling pathways during brain development and maturation
Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …
the brain including the regulation of neuronal migration, dendritic growth and branching …
Canonical and non-canonical reelin signaling
HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …
during neurodevelopment and is important for synaptic plasticity in the mature brain …
The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor
P Dlugosz, J Nimpf - International journal of molecular sciences, 2018 - mdpi.com
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density
lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the …
lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the …
De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism
M Riva, S Ferreira, K Hayashi, Y Saillour… - The Journal of Clinical …, 2024 - jci.org
Reelin (RELN) is a secreted glycoprotein essential for cerebral cortex development. In
humans, recessive RELN variants cause cortical and cerebellar malformations, while …
humans, recessive RELN variants cause cortical and cerebellar malformations, while …
Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway
C Leeb, C Eresheim, J Nimpf - Journal of Biological Chemistry, 2014 - ASBMB
Clusterin, also known as apolipoprotein J, is a multifunctional glycoprotein with the capacity
to interact with a wide range of molecules. Although clusterin has been implicated in a broad …
to interact with a wide range of molecules. Although clusterin has been implicated in a broad …
Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators
D Krstic, M Rodriguez, I Knuesel - 2012 - journals.plos.org
The extracellular signaling protein Reelin, indispensable for proper neuronal migration and
cortical layering during development, is also expressed in the adult brain where it modulates …
cortical layering during development, is also expressed in the adult brain where it modulates …
The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation
J Santana, MP Marzolo - Biochemical Journal, 2017 - portlandpress.com
Reelin is a large extracellular matrix protein with relevant roles in mammalian central
nervous system including neurogenesis, neuronal polarization and migration during …
nervous system including neurogenesis, neuronal polarization and migration during …
Regulation of Reelin functions by specific proteolytic processing in the brain
The secreted glycoprotein Reelin plays important roles in both brain development and
function. During development, Reelin regulates neuronal migration and dendrite …
function. During development, Reelin regulates neuronal migration and dendrite …
Altered balance of reelin proteolytic fragments in the cerebrospinal fluid of Alzheimer's disease patients
I Lopez-Font, MP Lennol, G Iborra-Lazaro… - International journal of …, 2022 - mdpi.com
Reelin binds to the apolipoprotein E receptor apoER2 to activate an intracellular signaling
cascade. The proteolytic cleavage of reelin follows receptor binding but can also occur …
cascade. The proteolytic cleavage of reelin follows receptor binding but can also occur …
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β
A Kobro-Flatmoen, C Battistin, RR Nair… - Brain …, 2023 - academic.oup.com
Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant
cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in …
cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in …