Reelin functions, mechanisms of action and signaling pathways during brain development and maturation

Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor

P Dlugosz, J Nimpf - International journal of molecular sciences, 2018 - mdpi.com
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density
lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the …

De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism

M Riva, S Ferreira, K Hayashi, Y Saillour… - The Journal of Clinical …, 2024 - jci.org
Reelin (RELN) is a secreted glycoprotein essential for cerebral cortex development. In
humans, recessive RELN variants cause cortical and cerebellar malformations, while …

Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway

C Leeb, C Eresheim, J Nimpf - Journal of Biological Chemistry, 2014 - ASBMB
Clusterin, also known as apolipoprotein J, is a multifunctional glycoprotein with the capacity
to interact with a wide range of molecules. Although clusterin has been implicated in a broad …

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators

D Krstic, M Rodriguez, I Knuesel - 2012 - journals.plos.org
The extracellular signaling protein Reelin, indispensable for proper neuronal migration and
cortical layering during development, is also expressed in the adult brain where it modulates …

The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation

J Santana, MP Marzolo - Biochemical Journal, 2017 - portlandpress.com
Reelin is a large extracellular matrix protein with relevant roles in mammalian central
nervous system including neurogenesis, neuronal polarization and migration during …

Regulation of Reelin functions by specific proteolytic processing in the brain

M Hattori, T Kohno - The journal of biochemistry, 2021 - academic.oup.com
The secreted glycoprotein Reelin plays important roles in both brain development and
function. During development, Reelin regulates neuronal migration and dendrite …

Altered balance of reelin proteolytic fragments in the cerebrospinal fluid of Alzheimer's disease patients

I Lopez-Font, MP Lennol, G Iborra-Lazaro… - International journal of …, 2022 - mdpi.com
Reelin binds to the apolipoprotein E receptor apoER2 to activate an intracellular signaling
cascade. The proteolytic cleavage of reelin follows receptor binding but can also occur …

Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β

A Kobro-Flatmoen, C Battistin, RR Nair… - Brain …, 2023 - academic.oup.com
Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant
cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in …