Nitrogen metabolism is an important physiological process that affects the survival and
virulence of Mycobacterium tuberculosis. M. tuberculosis's utilization of nitrogen in the …

Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to
remain one of the most devastating infectious diseases afflicting humans. Although there are …

Malaria, caused by Plasmodium protozoal parasites, remains a leading cause of morbidity
and mortality. The Plasmodium parasite has a complex life cycle, with asexual and sexual …

Background: Bisphosphonates are drugs commonly used for the medication and prevention
of diseases caused by decreased mineral density. Despite such important medicinal use …

Growing interest in the biological activity of aminobisphosphonates has stimulated the
development of methods for their synthesis. Although several general procedures were …

The heterogeneity of the clinical outcome of Mycobacterium tuberculosis (Mtb) infection may
be due in part to different strategies used by circulating strains to cause disease. This …

In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for
the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5 …

According to the latest World Health Organization (WHO) report, an estimated 10.6 million
people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major …

Abstract A series of 4-(pyridylamino)-and 4-(ethynylpyridine) quinazolines were successfully
prepared via Sonogashira cross-coupling and dechloroamination reactions on the C (4)-Cl …

Bisphosphonic acids, which are structural analogs of pyrophosphate, constitute a class of
compounds with very high potential for the construction of effective inhibitors of enzymes …