Abstract Ras converting enzyme 1 (Rce1) is an integral membrane endoprotease localized
to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three …

Heterotrimeric guanine nucleotide-binding proteins (G proteins) deliver external signals to
the cell interior, upon activation by the external signal stimulated G protein-coupled …

Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a
significant source of mortality in immunocompromised individuals, typically human …

The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both
in size and composition, upon entering the host. This cell wall remodeling is essential for …

Limited antifungal diversity and availability are growing problems for the treatment of fungal
infections in the face of increasing drug resistance. The echinocandins, one of the newest …

Cryptococcus sp. are basidiomycete yeasts which can be found widely, free-living in the
environment. Interactions with natural predators, such as amoebae in the soil, are thought to …

Introduction: Microbial pathogens undergo significant physiological changes during
interactions with the infected host, including alterations in metabolism and cell architecture …

Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and
emerging resistances. Next-generation antifungals therefore are needed urgently. We have …

The basidiomycetous fungus Sporisorium scitamineum causes a serious sugarcane smut
disease in major sugarcane growing areas. Sexual mating is essential for infection to the …

We used a temperature differential assay with the opportunistic fungal pathogen
Cryptococcus neoformans as a simple screening platform to detect small molecules with …