[HTML][HTML] A role for microfluidic systems in precision medicine

JM Ayuso, M Virumbrales-Muñoz, JM Lang… - Nature …, 2022 - nature.com
Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

[HTML][HTML] Viscoelastic microfluidics: Progress and challenges

J Zhou, I Papautsky - Microsystems & Nanoengineering, 2020 - nature.com
The manipulation of cells and particles suspended in viscoelastic fluids in microchannels
has drawn increasing attention, in part due to the ability for single-stream three-dimensional …

Detection of circulating tumor cells and their implications as a biomarker for diagnosis, prognostication, and therapeutic monitoring in hepatocellular carcinoma

JC Ahn, PC Teng, PJ Chen, E Posadas, HR Tseng… - …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is among the leading causes of worldwide cancer‐related
morbidity and mortality. Poor prognosis of HCC is attributed primarily to tumor presentation …

[HTML][HTML] Biomedical applications of microfluidic devices: a review

G Gharib, İ Bütün, Z Muganlı, G Kozalak, İ Namlı… - Biosensors, 2022 - mdpi.com
Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

Fundamentals and applications of inertial microfluidics: A review

J Zhang, S Yan, D Yuan, G Alici, NT Nguyen… - Lab on a Chip, 2016 - pubs.rsc.org
In the last decade, inertial microfluidics has attracted significant attention and a wide variety
of channel designs that focus, concentrate and separate particles and fluids have been …

Channel innovations for inertial microfluidics

W Tang, S Zhu, D Jiang, L Zhu, J Yang, N Xiang - Lab on a Chip, 2020 - pubs.rsc.org
Inertial microfluidics has gained significant attention since first being proposed in 2007
owing to the advantages of simplicity, high throughput, precise manipulation, and freedom …

Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

[HTML][HTML] Circulating tumor cell technologies

MM Ferreira, VC Ramani, SS Jeffrey - Molecular oncology, 2016 - Elsevier
Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …

Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics

ME Warkiani, BL Khoo, L Wu, AKP Tay, AAS Bhagat… - Nature protocols, 2016 - nature.com
Circulating tumor cells (CTCs) are rare cancer cells that are shed from primary or metastatic
tumors into the peripheral blood circulation. Phenotypic and genetic characterization of …

A review of sorting, separation and isolation of cells and microbeads for biomedical applications: microfluidic approaches

A Dalili, E Samiei, M Hoorfar - Analyst, 2019 - pubs.rsc.org
Several biomedical analyses are performed on particular types of cells present in body
samples or using functionalized microparticles. Success in such analyses depends on the …