Relevance of body composition in phenotyping the obesities

L Salmón-Gómez, V Catalán, G Frühbeck… - Reviews in Endocrine …, 2023 - Springer
Obesity is the most extended metabolic alteration worldwide increasing the risk for the
development of cardiometabolic alterations such as type 2 diabetes, hypertension, and …

What is the pipeline for future medications for obesity?

E Melson, U Ashraf, D Papamargaritis… - International Journal of …, 2024 - nature.com
Obesity is a chronic disease associated with increased risk of obesity-related complications
and mortality. Our better understanding of the weight regulation mechanisms and the role of …

Obesity in adults

I Lingvay, RV Cohen, CW le Roux, P Sumithran - The Lancet, 2024 - thelancet.com
Obesity has increased in prevalence worldwide and WHO has declared it a global epidemic.
Population-level preventive interventions have been insufficient to slow down this trajectory …

Obesity phenotypes and cardiovascular risk: from pathophysiology to clinical management

A Preda, F Carbone, A Tirandi, F Montecucco… - Reviews in Endocrine …, 2023 - Springer
Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

Towards precision medicine in non-alcoholic fatty liver disease

SM Francque - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden
vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and …

Obesity and diabetes

C Boutari, A DeMarsilis, CS Mantzoros - Diabetes Research and Clinical …, 2023 - Elsevier
Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

Towards an adiposity-related disease framework for the diagnosis and management of obesities

CM Perdomo, I Avilés-Olmos, D Dicker… - Reviews in Endocrine …, 2023 - Springer
Obesity is a complex disease that relapses frequently and associates with multiple
complications that comprise a worldwide health priority because of its rising prevalence and …

Brown adipose tissue-derived metabolites and their role in regulating metabolism

K Ziqubu, PV Dludla, SE Mabhida, BU Jack, S Keipert… - Metabolism, 2024 - Elsevier
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …

Obesity and cardiovascular risk: systematic intervention is the key for prevention

F Perone, A Pingitore, E Conte, G Halasz, M Ambrosetti… - Healthcare, 2023 - mdpi.com
Obesity is a serious public health issue and associated with an increased risk of
cardiovascular disease events and mortality. The risk of cardiovascular complications is …

Phenotyping the obesities: reality or utopia?

P Portincasa, G Frühbeck - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
In this thematic issue on phenotyping the obesities, prominent international experts offer an
insightful and comprehensive collection of articles covering the current knowledge in the …