Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Characterization of the SARS‐CoV‐2 E protein: sequence, structure, viroporin, and inhibitors

Y Cao, R Yang, I Lee, W Zhang, J Sun, W Wang… - Protein …, 2021 - Wiley Online Library
The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding
the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The …

Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS …

L Fabiani, M Saroglia, G Galatà, R De Santis… - Biosensors and …, 2021 - Elsevier
The diffusion of novel SARS-CoV-2 coronavirus over the world generated COVID-19
pandemic event as reported by World Health Organization on March 2020. The huge issue …

Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

S Ali, M Alam, F Khatoon, U Fatima, AM Elasbali… - Biomedicine & …, 2022 - Elsevier
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

S Zhang, L Wang, G Cheng - Molecular therapy, 2022 - cell.com
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …

[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development

S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational …

CB Mishra, P Pandey, RD Sharma… - Briefings in …, 2021 - academic.oup.com
The global pandemic crisis, coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed the lives of millions of …

Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2

U Breitinger, NS Farag, H Sticht… - The international journal of …, 2022 - Elsevier
Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …

Nucleic acid-based diagnostic tests for the detection SARS-CoV-2: an update

CY Yu, KG Chan, CY Yean, GY Ang - Diagnostics, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) began as a cluster of pneumonia cases in Wuhan, China …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …