Almost all of the 200 or so approved biopharmaceuticals have been produced in one of
three host systems: the bacterium Escherichia coli, yeasts (Saccharomyces cerevisiae …

Escherichia coli has been the most widely used host for the production of recombinant
proteins because it is the best characterized system in every aspect. Furthermore, the high …

Various high-throughput experimental techniques are routinely used for generating large
amounts of omics data. In parallel, in silico modelling and simulation approaches are being …

Genistin is one of the bioactive isoflavone glucosides found in legumes, which have great
nutraceutical and pharmaceutical significance. The market available isoflavones are …

Production of fuels and chemicals through microbial fermentation of plant material is a
desirable alternative to petrochemical‐based production. Fermentative production of …

White biotechnology is a term that is now often used to describe the implementation of
biotechnology in the industrial sphere. Biocatalysts (enzymes and microorganisms) are the …

A metabolic engineering perspective which views recombinant protein expression as a
multistep pathway allows us to move beyond vector design and identify the downstream rate …

The advent of recombinant DNA technology has revolutionized the strategies for protein
production. Due to the well-characterized genome and a variety of mature tools available for …

Escherichia coli has been widely used for the production of recombinant proteins. However,
the unbalances between host metabolism and recombinant biosynthesis continue to hamper …

Different hosts have been used for recombinant protein production, ranging from simple
bacteria, such as Escherichia coli and Bacillus subtilis, to more advanced eukaryotes as …