Lipogenesis inhibitors: therapeutic opportunities and challenges
B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
[HTML][HTML] The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …
[HTML][HTML] Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus
D Ferguson, BN Finck - Nature Reviews Endocrinology, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
[HTML][HTML] Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial
V Ratziu, L De Guevara, R Safadi, F Poordad… - Nature medicine, 2021 - nature.com
Nonalcoholic steatohepatitis (NASH), a chronic liver disease without an approved therapy, is
associated with lipotoxicity and insulin resistance and is a major cause of cirrhosis and …
associated with lipotoxicity and insulin resistance and is a major cause of cirrhosis and …
Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …
worldwide. With no Food and Drug Administration approved drugs, current treatment options …
[HTML][HTML] Therapeutic pipeline in nonalcoholic steatohepatitis
R Vuppalanchi, M Noureddin, N Alkhouri… - Nature reviews …, 2021 - nature.com
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …
Dysregulated lipid metabolism links NAFLD to cardiovascular disease
A Deprince, JT Haas, B Staels - Molecular metabolism, 2020 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …
[HTML][HTML] Dietary carbohydrates and fats in nonalcoholic fatty liver disease
H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
[HTML][HTML] Physiological and pathological roles of lipogenesis
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …