Lipogenesis inhibitors: therapeutic opportunities and challenges

B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

[HTML][HTML] The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments

G Targher, KE Corey, CD Byrne… - … reviews Gastroenterology & …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

[HTML][HTML] Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

D Ferguson, BN Finck - Nature Reviews Endocrinology, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

[HTML][HTML] Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial

V Ratziu, L De Guevara, R Safadi, F Poordad… - Nature medicine, 2021 - nature.com
Nonalcoholic steatohepatitis (NASH), a chronic liver disease without an approved therapy, is
associated with lipotoxicity and insulin resistance and is a major cause of cirrhosis and …

Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

[HTML][HTML] Therapeutic pipeline in nonalcoholic steatohepatitis

R Vuppalanchi, M Noureddin, N Alkhouri… - Nature reviews …, 2021 - nature.com
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

A Deprince, JT Haas, B Staels - Molecular metabolism, 2020 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …

[HTML][HTML] Dietary carbohydrates and fats in nonalcoholic fatty liver disease

H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

[HTML][HTML] Physiological and pathological roles of lipogenesis

YG Jeon, YY Kim, G Lee, JB Kim - Nature Metabolism, 2023 - nature.com
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …