Proteases involved in leader peptide removal during RiPP biosynthesis

SM Eslami, WA van der Donk - ACS Bio & Med Chem Au, 2023 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received
much attention in recent years because of their promising bioactivities and the portability of …

Targeted large-scale genome mining and candidate prioritization for natural product discovery

JJL Malit, HYC Leung, PY Qian - Marine Drugs, 2022 - mdpi.com
Large-scale genome-mining analyses have identified an enormous number of cryptic
biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products …

Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

H Li, W Ding, Q Zhang - RSC Chemical Biology, 2024 - pubs.rsc.org
Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a
diverse superfamily of natural products with immense potential for drug development. This …

A vast repertoire of secondary metabolites potentially influences community dynamics and biogeochemical processes in cold seeps

X Dong, T Zhang, W Wu, Y Peng, X Liu, Y Han… - Science …, 2024 - science.org
In deep-sea cold seeps, microbial communities thrive on the geological seepage of
hydrocarbons and inorganic compounds, differing from photosynthetically driven …

Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis

KS Makarova, B Blackburne, YI Wolf, A Nikolskaya… - Biology Direct, 2022 - Springer
Background Bacteria and archaea produce an enormous diversity of modified peptides that
are involved in various forms of inter-microbial conflicts or communication. A vast class of …

[HTML][HTML] Unravelling the secondary metabolome and biocontrol potential of the recently described species Bacillus nakamurai

F Nimbeshaho, G Nihorimbere, AA Arias… - Microbiological …, 2024 - Elsevier
In the prospect of novel potential biocontrol agents, a new strain BDI-IS1 belonging to the
recently described Bacillus nakamurai was selected for its strong in vitro antimicrobial …

Biocatalytic role of cytochrome P450s to produce antibiotics: A review

A Adhikari, S Shakya, S Shrestha… - Biotechnology and …, 2023 - Wiley Online Library
Cytochrome P450s belong to a family of heme‐binding monooxygenases, which catalyze
regio‐and stereospecific functionalisation of C–H, C–C, and C–N bonds, including …

Designing efficient floating bed options for the treatment of eutrophic water

S Nandy, D Kalra, A Kapley - AQUA—Water Infrastructure …, 2022 - iwaponline.com
Developing solutions for lake eutrophication has emerged as a priority area to address the
loss of ecosystem balance, reduction in aquatic biodiversity, and the potential production of …

Uncovering the diversity and distribution of biosynthetic gene clusters of prochlorosins and other putative RiPPs in marine Synechococcus strains

P Arias-Orozco, L Zhou, Y Yi, R Cebrián… - Microbiology …, 2024 - Am Soc Microbiol
Picocyanobacteria can synthesize a distinctive class of lanthipeptides referred to as
prochlorosins. They are classified within the Nif11 family and are subject to post …

A vast repertoire of secondary metabolites influences community dynamics and biogeochemical processes in cold seeps

X Dong, T Zhang, W Wu, Y Peng, X Liu, Y Han, X Chen… - bioRxiv, 2023 - biorxiv.org
In deep sea cold seeps, diverse microbial communities thrive on the geological seepage of
hydrocarbons and inorganic compounds. These chemosynthetically-driven communities are …