Recent advances in the monitoring, modelling and control of crystallization systems

ZK Nagy, G Fevotte, H Kramer, LL Simon - Chemical Engineering Research …, 2013 - Elsevier
Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

Advances and new directions in crystallization control

ZK Nagy, RD Braatz - Annual review of chemical and …, 2012 - annualreviews.org
The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

Crystal shape engineering

MA Lovette, AR Browning, DW Griffin… - Industrial & …, 2008 - ACS Publications
In an industrial crystallization process, crystal shape strongly influences end-product quality
and functionality, as well as downstream processing. In addition, nucleation events, solvent …

Recent progress of continuous crystallization

T Wang, H Lu, J Wang, Y Xiao, Y Zhou, Y Bao… - Journal of industrial and …, 2017 - Elsevier
Continuous crystallization has always been a hot topic in industrial crystallization. Many
efforts have been made to improve the continuous crystallization, either by designing novel …

Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform …

Y Barhate, H Kilari, WL Wu, ZK Nagy - Chemical Engineering Science, 2024 - Elsevier
A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …

Crystal population balance formulation and solution methods: a review

HM Omar, S Rohani - Crystal Growth & Design, 2017 - ACS Publications
Crystallization is an important part of many chemical industries. Efforts are being invested to
improve the performance of the crystallization process by designing novel crystallizers. An …

A comparative study of high resolution schemes for solving population balances in crystallization

S Qamar, MP Elsner, IA Angelov, G Warnecke… - Computers & Chemical …, 2006 - Elsevier
This article demonstrates the applicability and usefulness of high resolution finite volume
schemes for the solution of population balance equations (PBEs) in crystallization …

Homotopy analysis method and its convergence analysis for a nonlinear simultaneous aggregation-fragmentation model

S Yadav, S Keshav, S Singh, M Singh… - Chaos, Solitons & Fractals, 2023 - Elsevier
In this article, we focus on addressing the missing convergence analysis of the homotopy
analysis method (HAM) for solving pure aggregation and pure fragmentation population …

Simulation of mixing effects in antisolvent crystallization using a coupled CFD-PDF-PBE approach

XY Woo, RBH Tan, PS Chow… - Crystal Growth & Design, 2006 - ACS Publications
Antisolvent crystallization is widely used in the production of pharmaceuticals. Although it
has been observed experimentally that the crystal size distribution is strongly influenced by …

Evolutionary neural architecture search for surrogate models to enable optimization of industrial continuous crystallization process

SS Miriyala, KNS Pujari, S Naik, K Mitra - Powder Technology, 2022 - Elsevier
Optimal performance of the crystallization process is of utmost importance for industries
handling bulk commodity chemicals to pharmaceuticals. Such an optimization exercise …