Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Single-cell RNA-seq (scRNA-seq) has revolutionized modern genomics, but the large size of
myotubes and myofibers has restricted use of scRNA-seq in skeletal muscle. For the study of …

Quiescence regulation is essential for adult stem cell maintenance and sustained
regeneration. Our studies uncovered that physiological changes in mitochondrial shape …

With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and
with increased death, leading to defective muscle repair. To explore the molecular …

Skeletal muscle regeneration involves coordinated interactions between different cell types.
Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but …

Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective
tissues, blood vessels and nerve endings. Its main function is to provide motility to the body …

All multicellular organisms rely on intercellular communication networks to coordinate
physiological functions. As members of a dynamic social network, each cell receives …

Volumetric muscle loss (VML) is an acute trauma that results in persistent inflammation,
supplantation of muscle tissue with fibrotic scarring, and decreased muscle function. The cell …

During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle
volume and function impacting mobility and quality of life. Muscle loss is often associated …