Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has
recently gained interest, and different DDR inhibitors have been developed. Among them …

Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …

DDR (DNA damage response) defects in cells drive tumor formation by promoting DNA
mutations, which also provides cancer-specific vulnerabilities that can be targeted by …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

WEE1 kinase is renowned as an S-G2 checkpoint inhibitor activated by ATR-CHK1 in
response to replication stress. WEE1 inhibition enhances replication stress and effectively …

To identify genes whose loss confers resistance to CHK1 inhibitors, we perform genome-
wide CRISPR-Cas9 screens in non-small-cell lung cancer (NSCLC) cell lines treated with …

Simple Summary Cancer cells often show elevated replication stress and loss of cell cycle
checkpoints. The ataxia telangiectasia and Rad3-related (ATR) and WEE1 kinases play …

Deregulation of the DNA damage response (DDR) plays a critical role in the pathogenesis
and progression of many cancers. The dependency of certain cancers on DDR pathways …