Leaky gut as a danger signal for autoimmune diseases

Q Mu, J Kirby, CM Reilly, XM Luo - Frontiers in immunology, 2017 - frontiersin.org
The intestinal epithelial lining, together with factors secreted from it, forms a barrier that
separates the host from the environment. In pathologic conditions, the permeability of the …

The role of monocytes and macrophages in autoimmune diseases: a comprehensive review

WT Ma, F Gao, K Gu, DK Chen - Frontiers in immunology, 2019 - frontiersin.org
Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex

L Rizzetto, F Fava, KM Tuohy, C Selmi - Journal of autoimmunity, 2018 - Elsevier
Unresolved low grade systemic inflammation represents the underlying pathological
mechanism driving immune and metabolic pathways involved in autoimmune diseases …

Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells

AW Roberts, BL Lee, J Deguine, S John, MJ Shlomchik… - Immunity, 2017 - cell.com
Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll-like
receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms …

Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus

F Zhang, L Wu, J Qian, B Qu, S Xia, T La, Y Wu… - Journal of …, 2016 - Elsevier
Long noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …

TLR2 and TLR4 in autoimmune diseases: a comprehensive review

Y Liu, H Yin, M Zhao, Q Lu - Clinical reviews in allergy & immunology, 2014 - Springer
Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …

Lupus nephritis: a critical review

AT Borchers, N Leibushor, SM Naguwa… - Autoimmunity …, 2012 - Elsevier
Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …

The Th17/IL-17 axis and kidney diseases, with focus on lupus nephritis

FC Paquissi, H Abensur - Frontiers in Medicine, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

Toll-like receptors: potential targets for lupus treatment

Y Wu, W Tang, J Zuo - Acta Pharmacologica Sinica, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the
loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like …

SLE: another autoimmune disorder influenced by microbes and diet?

Q Mu, H Zhang, XM Luo - Frontiers in immunology, 2015 - frontiersin.org
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years
of study, the etiology of SLE is still unclear. Both genetic and environmental factors have …