Leaky gut as a danger signal for autoimmune diseases
The intestinal epithelial lining, together with factors secreted from it, forms a barrier that
separates the host from the environment. In pathologic conditions, the permeability of the …
separates the host from the environment. In pathologic conditions, the permeability of the …
The role of monocytes and macrophages in autoimmune diseases: a comprehensive review
WT Ma, F Gao, K Gu, DK Chen - Frontiers in immunology, 2019 - frontiersin.org
Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …
and are involved in regulation of the initiation, development, and resolution of many …
Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex
Unresolved low grade systemic inflammation represents the underlying pathological
mechanism driving immune and metabolic pathways involved in autoimmune diseases …
mechanism driving immune and metabolic pathways involved in autoimmune diseases …
Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells
Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll-like
receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms …
receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms …
Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus
Long noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …
TLR2 and TLR4 in autoimmune diseases: a comprehensive review
Y Liu, H Yin, M Zhao, Q Lu - Clinical reviews in allergy & immunology, 2014 - Springer
Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …
Lupus nephritis: a critical review
AT Borchers, N Leibushor, SM Naguwa… - Autoimmunity …, 2012 - Elsevier
Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …
erythematosus associated with considerable morbidity and mortality. A better understanding …
The Th17/IL-17 axis and kidney diseases, with focus on lupus nephritis
FC Paquissi, H Abensur - Frontiers in Medicine, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …
hyperreactivity of the immune response at various levels, including hyperactivation of …
Toll-like receptors: potential targets for lupus treatment
Y Wu, W Tang, J Zuo - Acta Pharmacologica Sinica, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the
loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like …
loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like …
SLE: another autoimmune disorder influenced by microbes and diet?
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years
of study, the etiology of SLE is still unclear. Both genetic and environmental factors have …
of study, the etiology of SLE is still unclear. Both genetic and environmental factors have …