The need to identify effective therapies for the treatment of psychiatric disorders is a
particularly important issue in modern societies. In addition, difficulties in finding new drugs …

Ibogaine is a powerful psychoactive substance that not only alters perception, mood and
affect, but also stops addictive behaviors. Ibogaine has a very long history of ethnobotanical …

Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of
depression and related disorders. The ability to promote both structural and functional …

The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the
sodium-and chloride-dependent recycling of serotonin into presynaptic neurons,–. Major …

Background: Ibogaine is a monoterpene indole alkaloid used in medical and nonmedical
settings for the treatment of opioid use disorder. Its mechanism of action is apparently novel …

Ibogaine may be effective for transitioning opioid and cocaine dependent individuals to
sobriety. American and European self-help groups provided public testimonials that …

There has recently been a resurgence of interest in psychedelic compounds based on
studies demonstrating their potential therapeutic applications in treating post-traumatic …

Context Ibogaine is the main alkaloid of the African shrub Tabernanthe iboga. It produces
hallucinogenic and psychostimulant effects, but it is currently known for the anti-addictive …

Background and aims Ibogaine is an indole alkaloid used in rituals of the African Bwiti tribe.
It is also used in non‐medical settings to treat addiction. However, ibogaine has been linked …

Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the
mechanisms that may underlie its anti-addictive effects are still not defined. This study aims …