Xanthones: biosynthesis and trafficking in plants, fungi and lichens

C Badiali, V Petruccelli, E Brasili, G Pasqua - Plants, 2023 - mdpi.com
Xanthones are a class of secondary metabolites produced by plant organisms. They are
characterized by a wide structural variety and numerous biological activities that make them …

Biotechnological production of hyperforin for pharmaceutical formulation

M Gaid, E Biedermann, J Füller, P Haas… - European Journal of …, 2018 - Elsevier
Hyperforin is a major active constituent of Hypericum perforatum (St. John's wort). It has
amazing pharmacological activities, such as antidepressant properties, but it is labile and …

[HTML][HTML] Phenolic profile and biological activity of Hypericum perforatum L.: Can roots be considered as a new source of natural compounds?

O Tusevski, M Krstikj, JP Stanoeva, M Stefova… - South African Journal of …, 2018 - Elsevier
The aim of this study was to evaluate the phytochemical composition, antimicrobial activity
and enzyme inhibitory properties of roots (RO), non-flower shoots (NFS) and flower shoots …

Exodermis and endodermis are the sites of xanthone biosynthesis in Hypericum perforatum roots

N Tocci, M Gaid, F Kaftan, AK Belkheir… - New …, 2018 - Wiley Online Library
Xanthones are specialized metabolites with antimicrobial properties, which accumulate in
roots of Hypericum perforatum. This medicinal plant provides widely taken remedies for …

Xanthones from roots, hairy roots and cell suspension cultures of selected Hypericum species and their antifungal activity against Candida albicans

D Zubrická, A Mišianiková, J Henzelyová, A Valletta… - Plant Cell Reports, 2015 - Springer
Key message Highest xanthone contents were found in Hypericum pulchrum and H.
annulatum untransformed roots. The best anti-Candida activity was obtained for hairy roots …

Antifungal activity of Mongolian medicinal plant extracts

C Giordani, G Simonetti, D Natsagdorj… - Natural product …, 2020 - Taylor & Francis
The in vitro antifungal activity of extracts obtained from 14 medicinal plants of the mongolian
flora were investigated by measuring their minimal inhibitory concentration (MIC) against …

In vitro antifungal activity of extracts obtained from Hypericum perforatum adventitious roots cultured in a mist bioreactor against planktonic cells and biofilm of …

G Simonetti, N Tocci, A Valletta, E Brasili… - Natural product …, 2016 - Taylor & Francis
Xanthone-rich extracts from Hypericum perforatum root cultures grown in a Mist Bioreactor
as antifungal agents against Malassezia furfur. Extracts of Hypericum perforatum roots …

Temperature-dependent growth and hypericin biosynthesis in Hypericum perforatum

Y Yao, T Kang, L Jin, Z Liu, Z Zhang, H Xing… - Plant Physiology and …, 2019 - Elsevier
Hypericum perforatum is a perennial herb that produces the anti-depression metabolite
hypericin (Hyp). While several efforts to increase Hyp production have been made, the …

Acetic acid acts as an elicitor exerting a chitosan-like effect on xanthone biosynthesis in Hypericum perforatum L. root cultures

A Valletta, G De Angelis, C Badiali, E Brasili, A Miccheli… - Plant cell reports, 2016 - Springer
Key message Acetic acid acts as a signal molecule, strongly enhancing xanthone
biosynthesis in Hypericum perforatum root cultures. This activity is specific, as demonstrated …

[PDF][PDF] In Vitro and in Silico Insights on the Biological Activities, Phenolic Compounds Composition of Hypericum perforatum L. Hairy Root Cultures.

O Tusevski, M Todorovska, JP Stanoeva… - Phyton (0031 …, 2023 - researchgate.net
Three Hypericum perforatum hairy root lines (HR B, HR F and HR H) along with non-
transformed roots were analyzed for phenolic compounds composition and in vitro enzyme …