Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by
natural killer (NK) cells and T cells that regulates immune responses during infection, cancer …

The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of
molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked …

Allogeneic cell therapeutics for cancer therapy or regenerative medicine are susceptible to
antibody-mediated killing, which diminishes their efficacy. Here we report a strategy to …

The genomic region encompassing the Major Histocompatibility Complex (MHC) contains
polymorphic frozen blocks which have developed by local imperfect sequential duplication …

The activating receptor, NKG2D, is expressed on a variety of immune effector cells and
recognizes divergent families of major histocompatibility complex (MHC) class I–related …

The major histocompatibility complex (MHC) genomic region is composed of a group of
linked genes involved functionally with the adaptive and innate immune systems. The class I …

The human MHC class I chain-related genes (MICA and MICB) are located within the HLA
class I region of chromosome 6. Their organization, expression and products differ …

Human and mouse NKG 2D ligands (NKG 2 DL s) are absent or only poorly expressed by
most normal cells but are upregulated by cell stress, hence, alerting the immune system in …

In addition the change of name of the gene HLA-DNA to HLA-DOA, as published in the
monthly updates, was confirmed, following further results showing that the gene codes for …